产品货号：
Z28043
中文名称：
TLE5/AES抗体
英文名称：
Anti-TLE5/AES Antibody
产品规格：
0.1mg
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TLE5/AES Antibody |
| 指标别名 | AES;AES 1;AES 2;Amino enhancer of split;ESP1;Gp130 associated protein GAM;GRG;GRG5;Protein ESP1;Protein GRG;TLE5 |
| 克隆性 | Polyclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | ELISA,WB,ICC,IF |
| 基因名称 | AES |
| 抗体来源 | Rabbit |
| 抗体类型 | IgG |
| 免疫原 | AES antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human AES.The immunogen is located within the last 50 amino acids of AES. |
| 计算分子量 | 22kDa |
| 成分 | AES Antibody is supplied in PBS containing 0.02% sodium azide. |
| 纯化方式 | AES Antibody is affinity chromatography purified via peptide column. |
| 浓度 | 1mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | 4℃可保存3个月，-20℃可保存1年。 |
| 背景资料 | Adhesion to extracellular matrix regulates cell survival through both integrin engagement and appropriate cell spreading.Anoikis is the molecular mechanism of apop-tosis induced by integrin detachment.Amino-terminal enhancer of split (AES) is a member of the Groucho/transducin-like enhancer of split (TLE) family of transcriptional regulators,a group of transcriptional co-repressors that play important roles in neurogenesis,segmentation,and sex determination.AES forms a complex with Bit1 (Bcl-2 inhibitor of transcription 1),a mitochondrial protein that is released into the cytoplasm upon onset of apoptosis.It has been suggested that this complex turns off a survival-promoting gene transcription program controlled by the TLE protein family.Interestingly,apoptosis of cells transfected with AES and Bit1 could be inhibited if the cells were allowed to attach to fibronectin through the alpha5beta1 integrin suggesting that the Bit1-AES pathway contributing to anoikis is regulated by integrins,and in particular,the alpha5beta1 integrin. |
| Uniprot ID | Q08117 |
| 基因名全称 | Amino-terminal enhancer of split |
| 蛋白名全称 | Amino-terminal enhancer of split |
| 推荐稀释比 | AES antibody can be used for the detection of AES by Western blot at 1 ～ 4μg/mL.Antibody can also be used for immunocytochemistry starting at 10μg/mL.For immunofluorescence start at 20μg/mL.Antibody validated:Western Blot in human samples;Immunocytochemistry in human samples and Immunofluorescence in human samples.All other applications and species not yet tested. |
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